The overall goal of the Heritage-DREAM breast cancer network inference challenge is to quickly and effectively advance our ability to infer causal signaling networks and predict protein phosphorylation dynamics in cancer. We provide extensive training data from experiments on four breast cancer cell lines stimulated with various ligands. The data comprise protein abundance time-courses under inhibitor perturbations.
Hill SM#, Heiser LM#, Cokelaer T, Unger M, Nesser NK, Carlin DE, Zhang Y, Sokolov A, Paull EO, Wong CK, Graim K, Bivol A, Wang H, Zhu F, Afsari B, Danilova LV, Favorov AV, Lee WS, Taylor D, Hu CW, Long BL, Noren DP, Bisberg AJ, The HPN-DREAM Consortium, Mills GB, Gray JW, Kellen M, Norman T, Friend S, Qutub AA, Fertig EJ, Guan Y, Song M, Stuart JM, Spellman PT, Koeppl H, Stolovitzky G+, Saez-Rodriguez J+ & Mukherjee S+. Inferring causal molecular networks: empirical assessment through a community-based effort. Nature Methods 13, 310–318 (2016). DOI:10.1038/nmeth.3773.