The purpose of the RA2-DREAM Challenge is to develop an automated method to quickly and accurately quantify the degree of joint damage associated with rheumatoid arthritis (RA). Based on radiographs of the hands and feet, a novel, automated scoring method could be applied broadly for patient care and research. We challenge participants to develop algorithms to automatically assess joint space narrowing and erosions using a large set of existing radiographs with damage scores generated by visual assessment of images by trained readers using standard protocols. The end result will be a generalizable, publicly available, automated method to generate accurate, reproducible and unbiased RA damage scores to replace the current tedious, expensive, and non-scalable method of scoring by human visual inspection.