The ICGC-TCGA DREAM Somatic Mutation Calling – RNA Challenge (SMC-RNA) is an international effort to improve standard methods for identifying cancer-associated rearrangements in RNA sequencing (RNA-seq) data. Leaders of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) cancer genomics projects are joining with Sage Bionetworks and IBM-DREAM to initiate this innovative open crowd-sourced Challenge [1-3].