This challenge explores the extent to which our current knowledge of signaling pathways, collected from a variety of cell types, agrees with cell-type specific high-throughput experimental data. Specifically, we ask the challenge participants to create a cell-type specific model of signal transduction using the measured activity levels of signaling proteins in HepG2 cell lines. The model, which can leverage prior information encoded in a generic signaling pathway provided in the challenge, should be biologically interpretable as a network, and capable of predicting the outcome of new experiments. More info
