challenges that appear ONLY on the closed page
CTD^2 Pancancer Drug Activity
Launched: December 2, 2019 (Now Open)
Leaderboard Closes: January 31, 2020
Final Submissions: February 13, 2020
Winners announced: 2-3 weeks after Final Submission
Over the last two years, the Columbia CTD2 Center developed PANACEA (Pancancer Analysis of Chemical Entity Activity), a comprehensive repertoire of dose response curves and molecular profiles representative of cellular responses to drug perturbations. PANACEA covers a broad spectrum of cellular contexts representative of poor outcome malignancies, including rare ones such as GIST sarcoma and gastroenteropancreatic neuroendocrine tumors (GEP-NETs). The goal of the CTD2 Pancancer Drug Activity DREAM Challenge is to foster the development and benchmarking of algorithms to predict targets of chemotherapeutic compounds from post-treatment transcriptional data.
Allen Institute Cell Lineage Reconstruction DREAM Challenge
Registration Opens: September, 2019
Launch: Mid-October, 2019 (Now Open)
Final Submissions: January, 2020
Winners Announced: March, 2020
CRISPR-based molecular tools allow the reconstruction of cell lineages based on the phylogenetic analysis of DNA mutations induced by CRISPR during development. The challenge - a partnership between The Allen Institute and DREAM - will comprise 3 subchallenges focused on reconstructing cell lineage trees of different sizes and nature. Through the usage for training purposes of experimental and in silico generated data sets, the goal of this challenge is to mobilize a larger community for evaluating new optimal tree-building methods.
Single Cell Signaling in Breast Cancer
Launch: August 2, 2019 (now open)
Webinar: August 20, 2019
This challenges uses genomic, transcriptomic, and proteomic measurements to evaluate signaling responses of 67 well-characterized breast cell lines to drug treatment at the single-cell level to better understand single-cell signaling and signaling modeling.
Preterm Birth Prediction: Transciptomics DREAM Challenge
Sub-challenge 1: May 4-Aug 15, 2019 (closed)
Top performers announced: September 13, 2019
Sub-challenge 2: Aug 15, 2019 - Dec 5, 2019 (Register now)
Top performers announced: January 3, 2020
Using whole blood gene expression data collected from pregnant women, participants will develop models to predict gestational age at blood draw and risk of preterm birth.
Malaria DREAM Challenge
Launch: April 30, 2019 (Closed)
Final Submissions: August 1, 2019
Top performers announced: September 1, 2019
The Malaria DREAM Challenge focuses on the infectious disease agent, malaria, with the goal of predicting the changing biology of Art-resistant malaria. The Challenge is open to anyone interested in contributing to the development of computational models that address important problems in advancing the fight against malaria.
IDG-DREAM Drug-Kinase Binding Prediction Challenge
Round 2 Spring 2019 (closed)
Round 1b of the IDG-DREAM Drug-Kinase Binding Prediction Challenge just ended and Round 2 will be opening to submissions on March 28th, 2019. In the upcoming round, participants are being asked to predict the binding affinity of a brand new set of drug-like molecules and kinases.
DREAM Single Cell Transcriptomics Challenge
August 31-Late November 2018
In this Challenge on Single-Cell Transcriptomics, participants will reconstruct the location of single cells in the Drosophila embryo using single-cell transcriptomic data.
Multi-targeting Drug DREAM Challenge
Open October 5, 2017 - February 26, 2018 (Closed)
This challenge seeks to diversify the methods used for rational design of drugs with multiple target proteins. Participants predict compounds active against two medically-relevant sets of targets, with predictions validated by commercial lab testing.
GA4GH/DREAM Workflow Execution Challenge
Open July - September 2017
The goal of this challenge is to evaluate systems and platforms for executing portable analysis workflows in the interest of developing common standards and best practices. Participants will run high quality genomics workflows in their system of choice to assess portability and reproducibility in a concrete way.
Parkinson’s Disease Digital Biomarker DREAM Challenge
July - October 2017 (Closed)
Using data collected through two Parkinson’s Disease mobile research studies, the goal of this challenge is to identify the best methods for processing mobile sensor data in order to distinguish gait and motor differences between Parkinson’s Disease patients and controls.