October 2, 2014
  • Dream Challenges pose fundamental questions about systems biology and translational science

DREAM Challenges pose fundamental questions about systems biology and translational medicine. Designed and run by a community of researchers from a variety of organizations, our challenges invite participants to propose solutions — fostering collaboration and building communities in the process. Expertise and institutional support are provided by Sage Bionetworks, along with the infrastructure to host challenges via their Synapse platform. Together, we share a vision allowing individuals and groups to collaborate openly so that the  “wisdom of the crowd” provides the greatest impact on science and human health.


Eduati F, Mangravite LM, et al; Prediction of human population responses to toxic compounds by a collaborative competition; Nature Biotechnology (2015) doi:10.1038/nbt.3299  


Learn more about what it is like participating in DREAM Challenges through our new video filmed at the 2014 DREAM conference in San Diego.  


DREAM 9.5 Prostate Cancer DREAM Challenge

Final results available. »more

DREAM 9.5 -DREAM Olfaction Prediction Challenge

Final results available. »more  
November 17, 2015

International team launches community competition to understand tumor origins and evolution

An international consortium of groups from Canada, the United States and the United Kingdom have come together to create an innovative, cloud-based, public challenge running on the Google Cloud Platform to optimize the discovery of genetically distinct groups of cells within cancers that could respond differently to treatment and have different risk of spreading. (Read more)

November 10, 2015

THINK: Applying Big Data Analytics to Answer More Questions About ALS

Each year, more than 5,600 Americans are diagnosed with Amyotrophic Lateral Sclerosis (ALS), also called Lou Gehrig’s Disease. This diagnosis usually prompts more questions from patients and family members about longevity and quality of life than what physicians can immediately answer. (Read more)

November 5, 2015

Prize4Life, Sage Bionetworks and DREAM Announce Winners of ALS Stratification Challenge

Today, Prize4Life, Sage Bionetworks and the DREAM community announced the winners of the DREAM ALS Stratification Prize4Life Challenge, a global data analysis competition to computationally identify different subgroups of ALS patients. In ALS, there is currently no way to determine whether someone living with the disease will survive the average of 3-5 years after diagnosis or live with ALS for decades. The goal of the Challenge is to find answers that may inform clinical practice, new trial designs, and ultimately personalized approaches to the discovery and development of new ALS medicines.  (Read more)