October 2, 2014
  • COVID-19 EHR DREAM Challenge

    COVID-19 EHR DREAM Challenge

    The rapid rise of COVID-19 has challenged healthcare globally. Due to the importance and emergent need for better understanding of the condition and the development of patient specific clinical risk scores and early warning tools, we have developed a platform to support testing analytic and machine learning hypotheses on clinical data without data sharing as a platform to rapidly discover and implement approaches for care. This Challenges aims to identify risk factors that lead to a positive test utilizing electronic health recorded data mapped to the OMOP Common Data Model. REGISTER NOW

  • CTD^2 Pancancer Chemosensitivity DREAM Challenge

    CTD^2 Pancancer Chemosensitivity DREAM Challenge

    Current round: Pre-competition
    Registration Open: April 20, 2020
    Webinar: April 28, 2020 Click here for attendance options.
    Launch: April 28, 2020
    Leaderboard Round Opens: April 28, 2020
    Leaderboard Round Closes: June 29, 2020, 5PM Pacific Time
    Final Round Opens: June 29, 2020, 5PM Pacific Time
    Final Round Closes: July 27, 2020, 5PM Pacific Time
    Winners Announced: August, 2020

    The goal of this Challenge is to foster development and benchmarking of algorithms to predict the sensitivity, as measured by the area under the dose-response curve, of a cell line to a compound based on the baseline transcriptional profiles of the cell line.

  • Metadata Automation DREAM Challenge

    Metadata Automation DREAM Challenge

    Open Phase: Ends 2/9/2020
    Webinar: 1/30/2020
    Leaderboard Phase Round 1: 2/10/2020 - 3/9/2020
    Leaderboard Phase Round 2: 3/10/2020 - 4/9/2020
    Validation Phase: 4/10/2020 - 4/24/2020
    Winners Announced: early May 2020

    We aim to significantly lower the burden of adding coherent metadata annotations across the data ecosystem to streamline and enable both retrospective harmonization as well as data query, discovery and interpretation. This challenge addresses this time-consuming task with automated metadata annotation of structured data.

  • CTD^2 Beat AML DREAM Challenge

    CTD2 Beat AML DREAM Challenge

    Open Phase: Ends 1/6/2020
    Webinar: 1/6/2020 11:00 AM PST
    Leaderboard Phase: 1/6/2020 - 3/2/2020
    Validation Phase: 3/2/2020 - 4/28/2020
    Winners Announced: early May 2020

    The goal of the Beat AML DREAM Challenge is to define patient subpopulations tailored to individual treatments by discovering (genomic and transcriptomic) biomarkers of drug sensitivity, as evaluated on an unpublished cohort of patients from the BeatAML project.


  • RA2 DREAM Challenge

    RA2 DREAM Challenge: Automated Scoring of Radiographic Joint Damage

    Launch: November 4, 2019 (Now open)
    Final Submissions: May 31, 2020
    Winners Announced: July 31, 2020

    Rheumatoid Arthritis (RA) is a debilitating disease that causes joint damage in the hands and feet due to inflammation. Accurate measuring of joint damage and progression of disease is essential in assessing the severity of disease, along with being able to monitor patient response to treatment. Scoring of X-ray images is tedious and there can be a great deal of variability between rheumatologists when applying scoring methods. We will leverage nearly 1000 images across a range of disease severities to challenge participants to develop an automated scoring algorithm with the goal of making clinical scoring fast and consistent; this will aid rheumatologists in making the best decisions for patients.


Designed and run by a community of researchers from a variety of organizations, DREAM Challenges invite participants to propose solutions to fundamental biomedical questions — fostering collaboration and building communities in the process. Sage Bionetworks provides the expertise and infrastructure to host challenges via their Synapse platform. Together, we share a vision allowing individuals and groups to collaborate openly so that the “wisdom of the crowd” provides the greatest impact on science and human health.

If you have an idea for a DREAM challenge, please contact us here.


Guinney J, Saez-Rodriguez J.; Alternative models for sharing confidential biomedical data.; Nat Biotechnol. 2018 May 9;36(5):391-392. doi: 10.1038/nbt.4128.  


The participants in the Annual DREAM Conference in NYC in Nov helped us "crowdsource" our latest video. Thanks to all that allowed us to take your pictures or sent in pictures!  

RECOMB/ISCB with DREAM Conference Info

RECOMB/ISCB RSG with DREAM Conference is in its 13th year! This premier annual meeting for DREAM will offer presentations by best performers from DREAM Challenges in the past year. There will also be Keynotes and Open Papers presented. Please join us virtually Nov 16-18, 2020.
November 8, 2019

DREAM Challenges Announces Changes in its Leadership that Support a Rich Future in Open Benchmarking


SEATTLE – DREAM Challenges has announced changes to its governance and leadership to reflect its vision for future growth. DREAM is a volunteer organization of more than 30,000 solvers focused on crowd-sourced challenges to benchmark informatic algorithms in biomedicine. The peer-based governance process has been formalized by charter and will be led by a volunteer board of directors, with a rotating chair position. Dr. Justin Guinney, VP of Computational Oncology at Sage Bionetworks, is the new chair.

Sage Bionetworks has partnered with DREAM since 2013, providing the technology platform, governance protocols, and data science expertise that underpin DREAM Challenges. The DREAM methodology has already been adopted by other groups that host challenges. By assuming a key role in the charter, Sage is making a clear commitment to upholding and growing DREAM’s mission to enable collaborative science.

DREAM was founded in 2006 by Dr. Gustavo Stolovitzky, who announced this week at the 14th DREAM Challenges Conference in New York that he would be stepping back from actively leading the organization, though he will remain involved. Dr. Stolovitzky, the Director of the IBM Translational Systems Biology and Nanobiotechnology Program at IBM’s Thomas J. Watson Research Center, will continue to support the mission of DREAM as Chair Emeritus and DREAM Board Director.

“I’m proud of the community we’ve created with the DREAM Challenges,” said Dr. Stolovitzky. “Our approach has confirmed that data sharing and collaborative science is a powerful methodology not only for scientific research but also for the rigorous evaluation of algorithmic performance that is necessary for reproducible science. There is much to discover yet and it will be a pleasure to watch DREAM evolve under Justin Guinney’s creative leadership.”

Dr. Guinney, who has served on the DREAM board since in 2013, will work closely with Dr. Stolovitzky and the board to develop a vision for how to extend the reach of DREAM Challenges to untapped domains that are poised to benefit from crowd-sourced solutions. Dr. Guinney’s contributions to DREAM have focused on advanced predictive modeling in diagnostic mammography screening and drug combination therapy; prognostic modeling in breast and prostate cancer and multiple myeloma; and, recently, a benchmarking challenge using electronic healthcare records.

“The power of DREAM is the power to connect,” said Dr. Guinney, whose work at Sage Bionetworks focuses on integrative data analysis for prognostic and predictive modeling of cancer outcomes and response to therapy. “Building on the foundation of our past successes, DREAM will continue to serve its mission of connecting individuals and teams with data and algorithms to tackle complex biomedical questions.”

Under Dr. Stolovitzky’s leadership, DREAM evolved into a model of how to use crowdsourcing and open science in biomedicine, with first-of-its-kind Challenges that led to scientific insights in a wide range of research topics including biological network inference, cancer genomics and pharmacogenomics, predicting disease progression, and medical imaging among others. DREAM has launched more than 60 challenges that have engaged and touched the careers of thousands of scientists from dozens of institutions across the public and private sectors around the world.

“Having been involved with DREAM all these years, it’s an honor to help usher in the next generation of Challenges,” said Dr. Guinney.

In addition to Drs. Guinney and Stolovitzky, other board directors include: Dr. Laura Heiser, Oregon Health Sciences University; Dr. Paul Boutros, University of California, Los Angeles; Dr. James Costello, University of Colorado; Dr. Pablo Meyer, IBM; and Dr. Julio Saez-Rodriguez, Heidelberg University. More information about the DREAM leadership and governance can be found at www.dreamchallenges/people.


DREAM (Dialogue on Reverse Engineering and Assessment Methods) Challenges emerged in 2006 to leverage the wisdom of the multidisciplinary scientific community to solve fundamental and difficult questions in biomedical research. DREAM’s methodology is based on crowd-sourcing scientific Challenges, fostering open and collaborative research, and promoting data sharing. In 2013, DREAM partnered with Sage Bionetworks, which developed and administers the technology platform that underpins DREAM Challenges.


Sage Bionetworks is a nonprofit biomedical research and technology development organization that was founded in Seattle in 2009. Our focus is to develop and apply open practices to data-driven research for the advancement of human health. Our interdisciplinary team of scientists and engineers work together to provide researchers access to technology tools and scientific approaches to share data, benchmark methods, and explore collective insights, all backed by Sage’s gold-standard governance protocols and commitment to user-centered design. Sage is a 501c3 and is supported through a portfolio of competitive research grants, commercial partnerships, and philanthropic contributions.

Contact: Hsiao-Ching Chou

May 30, 2019

Idea Competition Winner Announced for the CTSA Program

The CD2H Idea Competition for the CTSA Program is pleased to announce the winner of the Idea Challenge Competition: University of Alabama, Birmingham “Automated Scoring of Radiographic Damage in Rheumatoid Arthritis” (PI S. Louis Bridges). This will be developed into an upcoming DREAM Challenge. (read more)