October 2, 2014
  • Dream Challenges pose fundamental questions about systems biology and translational science

DREAM Challenges pose fundamental questions about systems biology and translational medicine. Designed and run by a community of researchers from a variety of organizations, our challenges invite participants to propose solutions — fostering collaboration and building communities in the process. Expertise and institutional support are provided by Sage Bionetworks, along with the infrastructure to host challenges via their Synapse platform. Together, we share a vision allowing individuals and groups to collaborate openly so that the  “wisdom of the crowd” provides the greatest impact on science and human health.


Hill S,  Heiser L, et al Inferring causal molecular networks: empirical assessment through a community based effort Nature Methods, 13, 310–318 (2016) (doi:10.1038/nmeth.3773)  


Learn more about the science of the DREAM Challenges in our latest video produced at the 2015 DREAM Conference in Philadelphia.  


DREAM 10 – ALS Stratification Prize4Life Challenge

Final results available. »more

DREAM 9.5 Prostate Cancer DREAM Challenge

Final results available. »more

DREAM 9.5 -DREAM Olfaction Prediction Challenge

Final results available. »more  
June 29, 2016

At Cancer Moonshot Summit, Vice President Biden Announces New Actions to Accelerate Progress Toward Ending Cancer As We Know It

The Cancer Moonshot is hosting a summit at Howard University, in Washington, D.C.  In conjunction with the Summit, the Vice President is announcing a set of new public and private sector actions to drive progress toward ending cancer as we know it.  Federal agencies have come together as part of the Cancer Moonshot Task Force and are announcing today additional investments, improved policies, and new private sector partnerships focused on catalyzing new scientific breakthroughs, unleashing the power of data, accelerating bringing new therapies to patients, strengthening prevention and diagnosis, and improving patient access and care.  Among the initiatives announced today was the official launch of the first of the Coding4Cancer (C4C) Challenges: the Digital Mammography DREAM Challenge. (Read more.)

June 20, 2016

Initial Results from the AZ-Sanger Drug Combo Prediction Challenge Presented

IMG_4582DREAM recently both partnered with the Boston Computational Biology and Bioinformatics network and joined the Systems Biology of Human Disease conference to announce winners and present the initial results from the AstraZeneca-Sanger Drug Combination Prediction Challenge.   Jonathan Dry and Julio Saez-Rodriguez reported to an audience of over 80 computational biologists how this Challenge became the highest participated of any DREAM challenge to date, with participation from across the globe including individuals qualified in a wide range of disciplines.  They highlighted the winning method from Yuanfang Guan (Department of Computational Medicine & Bioinformatics, University of Michigan), and revealed fascinating early insight to the patterns of data and method usage most influential in successful predictions.  DREAM were also delighted to welcome Peter Sorger (Professor of Systems Pharmacology, Harvard Medical School) to describe his own take on crowdsourcing and drug combinations at the BCBB event.

May 18, 2016

Challenges: Crowdsourced solutions

A commentary in the most recent issue of the journal Nature discusses how DREAM Challenges and other open competitions bring new minds, skills and collaborations to problems in biomedical research. (Read More)