October 2, 2014
  • Community insight Community impact

DREAM Challenges pose fundamental questions about systems biology and translational medicine. Designed and run by a community of researchers from a variety of organizations, our challenges invite participants to propose solutions — fostering collaboration and building communities in the process. Expertise and institutional support are provided by Sage Bionetworks, along with the infrastructure to host challenges via their Synapse platform. Together, we share a vision allowing individuals and groups to collaborate openly so that the  “wisdom of the crowd” provides the greatest impact on science and human health.


Jonathan R. Karr, Williams A, Zucker J, et al;  Summary of the DREAM8 Parameter Estimation Challenge: Toward Parameter Identification for Whole-Cell Models; PLOS (2015) DOI: 10.1371/journal.pcbi.1004096  


Learn more about what it is like participating in DREAM Challenges through our new video filmed at the 2014 DREAM conference in San Diego.  


The Broad-DREAM Gene Essentiality Prediction Challenge

Final results available. »more

ICGC-TCGA-DREAM Somatic Mutation Calling Challenge

Final results available. »more

The Rheumatoid Arthritis Responder Challenge

Final results available. »more

Alzheimer’s Disease Big Data DREAM Challenge #1

Final results available. »more

 Acute Myeloid Leukemia (AML) Outcome Prediction Challenge

Final results available.  »more
July 8, 2015

Applied Knowledge Building networks for translation: how to use DREAM challenges and the Synapse platform as a research strategy

A special session at  the ISMB/ECCB Conference in Dublin, Ireland on July 11 will explain the rationale behind running a DREAM Challenge, the steps involved from both sides of the process (organizers and participants), the lessons learned, and the potential uses of DREAM Challenges in education. A hands-on exercises with the Synapse platform will also be featured. (Read more.)

June 23, 2015

Prize4Life, Sage Bionetworks and DREAM Launch an Open Science Challenge

The  DREAM Challenge goals is to find clues to understanding heterogeneity in patients with Amyotrophic Lateral Sclerosis (ALS).  The DREAM ALS Stratification Prize4Life Challenge brings together patients, clinical researchers, data scientists and pharmaceutical industry leaders to computationally identify for the first time different subgroups of ALS patients, to pave the way for potential new treatments.  (read more)