%PDF-1.3
%
2 0 obj
<>
endobj
4 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
3 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
1 0 obj
<>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
5 0 obj
<>stream
2012-01-28T11:52:08+05:30
Arbortext Advanced Print Publisher 9.0.114/W
2012-05-28T17:45:44-07:00
Acrobat Distiller 8.1.0 (Windows)
application/pdf
untitled
uuid:5c550ba8-2c2e-4609-8601-9f5440ad21e4
uuid:9c2b2b7c-985e-42dc-90b9-1688bb2d2486
endstream
endobj
6 0 obj
<>stream
x+ |
endstream
endobj
7 0 obj
<>stream
xS**T0T0 BiUD* 8
endstream
endobj
8 0 obj
<>stream
8;X]O>EqN@%''O_@%e@?J;%+8(9e>X=MR6S?i^YgA3=].HDXF.R$lIL@"pJ+EP(%0
b]6ajmNZn*!='OQZeQ^Y*,=]?C.B+\Ulg9dhD*"iC[;*=3`oP1[!S^)?1)IZ4dup`
E1r!/,*0[*9.aFIR2&b-C#soRZ7Dl%MLY\.?d>Mn
6%Q2oYfNRF$$+ON<+]RUJmC0InDZ4OTs0S!saG>GGKUlQ*Q?45:CI&4J'_2j$XKrcYp0n+Xl_nU*O(
l[$6Nn+Z_Nq0]s7hs]`XX1nZ8&94a\~>
endstream
endobj
9 0 obj
[/Indexed/DeviceRGB 255 8 0 R]
endobj
10 0 obj
<>stream
8;Z]!;%eL8#Xl6'"h@C+D).t<"Ipd3Rf0I]0lH[cNFcG-SOek5K[m-82(Qk+4]^V8
c34XD"%ig+X[oE.M@lU-kH
Ko:*Ofj2oMY'+#8jl!F"3^(M
endstream
endobj
11 0 obj
<>
endobj
12 0 obj
<>
endobj
13 0 obj
<>
endobj
15 0 obj
<>
endobj
14 0 obj
<>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Thumb 10 0 R/MediaBox[0 0 612 792]/Rotate 0>>
endobj
23 0 obj
<>/ProcSet[/PDF/Text]/Font<>>>
endobj
18 0 obj
<>
endobj
19 0 obj
<>
endobj
20 0 obj
<>
endobj
16 0 obj
<>stream
/GS1 gs
BT
/F1 1 Tf
17.9328 0 0 17.9328 483.9873 731.962 Tm
0 0 0 rg
0 Tc
0 Tw
(Preface)Tj
-16.648 -4.7706 TD
[(Preface:)-336(RECOMB)-337.4(Systems)-333.1(Biology,)]TJ
-3.7557 -1.2235 TD
[(Regulatory)-334.5(Genomics,)-338.2(and)-332.9(DREAM)-334.9(2011)-333.1(Special)-336(Issue)]TJ
/F2 1 Tf
27.7155 0 0 27.7155 106.5826 554.2298 Tm
(O)Tj
/F3 1 Tf
9.9626 0 0 9.9626 129.2598 566.0786 Tm
[(ver)-325.9(the)-326.5(past)]TJ
/F1 1 Tf
6.032 0 TD
(10)Tj
/F3 1 Tf
1.3259 0 TD
(years)Tj
/F1 1 Tf
2.4925 0 TD
[(,)-324.7(the)-325.5(stud)-7(y)-325.1(o)0(f)-322.2(cel)-8.6(l)-322.2(regulatory)-333.7(processe)-10.1(s)-326.3(and)-328.4(their)-326.1(integr)-8.2(ation)-324.1(wi)-8.2(thin)-321.6(com)-7.6(plex)]TJ
-9.8503 -1.2007 TD
[()48.5(systems-)-11.1(level)41.3()-253.1(models)-258.5(of)-253.9(cell)-256.8(physi)-7.8(ology)-257(and)-254.5(cell)-256.8(path)-7.6(ology)-257(has)-255.7(ourished)-8.1(,)-256.5(with)-257.2(geometri)-9.3(c)-252.9(increas)-10.9(e)]TJ
-2.1738 -1.2007 TD
[(in)-203.5(sci)-8(entic)-212.1(publica)-8.7(tions)-209.7(and)-208.9(impact)-210.7(on)-206.4(biology.)-210.4(Withi)-9(n)-205.6(the)-211.7(broad)-206.8(spectru)-9.1(m)-209.2(o)0(f)-208.4(molecular)-216.7(biology)-210(discipli)-8.7(nes,)]TJ
T*
[(system)-9.3(s)-349.1(biology)-352.3(and)-351.2(regul)-10.3(atory)-351.8(genom)-9.1(ics)-349.5(are)-355(perhaps)-353.5(the)-354(ones)-353.2(that)-351.8(have)-353.8(b)-6.5(een)-353(most)-352(charact)-11.5(erized)-356.1(by)-348.7(the)]TJ
T*
[(seaml)-9.2(ess)-325.1(and)-328.4(un)-7.2(ique)-326.3(integr)-8.2(ation)-329.8(of)-327.9(computa)-9.5(tional)-327.6(and)-334.1(experiment)-12.6(al)-324.7(science)-10.7(s,)-326.7(allow)-9.4(ing)-323.7(the)-331.2(rapid)-329(transf)-8.6(or-)]TJ
T*
[(mation)-368.2(of)-362(high-th)-7.2(roughp)-6.6(ut)-362.8(data)-367.9(into)-361.4(com)-7.6(plex)-360.4(com)-7.6(putational)-369.4(mode)-8.4(ls,)-364.4(of)-362(models)-366.7(into)-367.1(testable)-368.1(hypot)-6.6(heses,)]TJ
T*
[(and)-220.3(nally)-221.7(of)-219.7(hypot)-6.6(heses)-220.3(into)-224.8(knowled)-8.1(ge)-219.6(via)-217.4(exper)-9.4(imental)-225.6(validati)-9.3(on.)-218.1(Today,)-222(these)-221.9(disc)-8.8(iplines)-221.5(are)-224.1(achieving)]TJ
T*
[(matur)-8.2(ity,)-395.2(as)-397.2(also)-401.4(demonst)-8.9(rated)-399.1(by)-399.9(the)-399.5(creation)-400.2(of)-401.8(several)-403.6(universit)-8.7(y)-393.4(depar)-9.4(tments,)-403.9(centers,)-404(and)-396.7(insti)-7.6(tutes)]TJ
0 -1.195 TD
[(dedicat)-10.5(ed)-270.8(to)-271.7(their)-274.9(study)-275.2(and)-271.5(by)-269(the)-274.3(popul)-6.6(arity)-274.9(and)-271.5(grow)-9(th)-271.7(of)-271(meeting)-274(such)-279.2(as)-272(the)-274.3(RECOMB)-280.5(Conference)-279.5(on)]TJ
0 -1.2007 TD
[(Systems)-197.1(Biol)-7.6(ogy,)-190.5(Regula)-9.9(tory)-189.9(Gen)-8(omics,)-195.6(and)-191.9(DREA)-9.7(M)-190.5(Challenge)-11.1(s.)-190.1(Th)-7(is)-187.6(event)-10.1(,)-188.2(which)-194.4(is)-193.3(current)-9.9(ly)-186.4(in)-192.1(its)-191.1(four)-7(th)]TJ
T*
[(edition)-345.5(as)-345.9(a)-338.3(joint)-347.8(meeting,)-348.4(is)-341.2(particu)-10.7(larly)-343.2(relevan)-9.7(t)-339.3(a)0(s)-345.9(i)0(t)-337.1(com)-7.6(bines)-345.3(uniqu)-6.6(e)-338.3(com)-7.6(putational)-346.6(and)-345.5(exper)-9.4(imental)]TJ
T*
[(perspect)-11.7(ives,)-225.4(while)-231.3(also)-230.7(establish)-9.7(ing)-227(a)-224.5(uniqu)-6.6(e)-224.5(frame)-231.1(of)-225.4(reference,)-238.3(via)-223.1(the)-228.8(DREA)-9.8(M)-224.7(challe)-9.8(nges,)-228.3(to)-226.2(objectively)]TJ
T*
[(gauge)-286.2(the)-285.7(progress)-287.4(of)-282.3(our)-283.1(ability)-285.6(to)-283.1(dissect)-284.3(regul)-10.3(atory)-283.5(networ)-9.3(ks)-281.6(and)-282.9(to)-283.1(model)-285(biological)-289.7(processe)-10.1(s.)]TJ
1.0015 -1.2007 TD
[(The)-436.4(4th)-431.8(edition)-436.5(of)-436(the)-433.6(Joint)-437.3(RECOMB)-439.8(Con)-7(ference)-443.2(on)-428.3(Sy)-6.4(stems)-435.4(Biol)-7.6(ogy,)-435.2(Regulatory)-438.8(Gen)-8(omics,)-434.6(and)]TJ
-1.0015 -1.2007 TD
[(DREA)-9.7(M)-469.3(Challenge)-11.1(s)-468.6(was)-475.8(held)-468.5(in)-470.9(Barce)-10.2(lona,)-474.6(Spain)-468.5(on)-473.9(Octobe)-9.1(r)-469.4(1419,)-470.8(2011.)-475.7(The)-470.5(conferen)-9.7(ce)-471.7(brough)-6.6(t)]TJ
T*
[(togethe)-8.7(r)-236.1(com)-7.6(putational)-244.2(and)-243.1(exper)-9.4(imental)-242.6(scient)-9.2(ists)-238.6(to)-243.3(discuss)-241.1(curr)-8.8(ent)-240.2(researc)-11.9(h)-234.1(dir)-7(ections)-243.3(and)-243.1(latest)-245.2(nding)-6.6(s,)]TJ
0 -1.195 TD
[(and)-254.5(to)-249(establ)-9.2(ish)-250.9(new)-252.7(collabo)-8.7(ration)-8.2(s)-246.7(towar)-8.6(ds)-247.4(a)-252.9(system)-9.3(s-level)-256.6(under)-7.6(standing)-253.6(of)-253.9(gene)-251.3(regulat)-10.7(ion)-249.7(and)-254.5(modeling)]TJ
0 -1.2007 TD
[(of)-367.7(biologi)-7.9(cal)-367.1(system)-9.3(s.)-366.5(The)-368.1(confe)-9.4(rence)-369.7(include)-8.7(d)-365(oral)-373.8(presentations)-380.7(from)-369(accepte)-11.3(d)-365(full-len)-8.7(gth)-369.3(manuscript)-12(s)]TJ
T*
[(and)-362.6(from)-363.3(a)-361.1(few)-362.8(high-qual)-10.5(ity)-360.6(abstrac)-10.9(ts,)-358.7(as)-363(well)-361.4(as)-363(invite)-9(d)-359.3(present)-9.2(ations)-365.9(from)-363.3(thought)-363.7(leaders)-369.4(in)-357.1(the)-365.3(eld.)]TJ
T*
[(Accept)-10.9(ed)-378.9(full-)-7.6(length)-381.8(man)-7.6(uscripts)-387.6(that)-380.2(const)-9.6(itute)-383.8(signica)-9.9(nt)-379.9(theoretic)-11.1(al)-381.7(advanc)-9.9(es)-380.1(to)-379.9(the)-382.4(elds)-384.3(o)-6.5(f)-378.3(system)-9.3(s)]TJ
T*
[(biology)-238.5(and)-243.1(regulatory)-242.6(genom)-9.1(ics)-235.7(have)-239.9(been)-239.9(com)-7.6(bined)-236(in)-237.6(a)-235.9(collec)-9.8(tion)-236.2(that)-238(is)-238.8(present)-9.2(ed)-236.6(in)-237.6(the)-234.5(curr)-8.8(ent)-234.5(iss)-7.4(ue)-236.6(of)]TJ
T*
(the)Tj
/F4 1 Tf
1.5649 0 TD
[(Journa)-7.6(l)-333.6(o)0(f)-334.3(Computat)-8.9(ional)-339.4(Biology.)]TJ
34.1319 -1.747 TD
[(GUEST)-340.7(EDIT)-8(ORS)]TJ
.6999 -1.2007 TD
[(Andrea)-337.4(Cali)-7.6(fano)]TJ
-7.2099 -1.2007 TD
[(Professor)-10.3(,)-330.4(Biom)-9.6(edical)-338(Inform)-8.7(atics)]TJ
-6.0434 -1.2007 TD
[(Direc)-9.6(tor,)-336.7(Columbi)-8.1(a)-330.8(Ini)-7(tiative)-338.6(in)-334.3(System)-10.3(s)-332(Biolo)-9.1(gy)]TJ
-11.4551 -1.2007 TD
[(Director)-10.1(,)-330.4(C)0(e)-8(nter)-333.2(for)-336.3(the)-336.9(Mul)-7.8(tiscale)-337.1(An)-7(alysis)-338.6(of)-334.3(Genetic)-344.5(Network)-10.9(s)-332(\()-82.4(MAG)-8.8(Net\))]TJ
-.6829 -1.2007 TD
[(Associ)-11.3(ate)-336.9(Director)-340.2(for)-336.3(Bioi)-8.4(nformati)-8.1(cs,)-334.9(Irving)-342.3(Cancer)-338.4(Resear)-10.3(ch)-333.4(Ce)-8(nter)-333.2(\(ICRC)-11.3(\))]TJ
23.7182 -1.2007 TD
[(Colum)-9.5(bia)-335.1(Univer)-10.3(sity)]TJ
-.1195 -1.195 TD
[(New)-337.9(York,)-335.7(Ne)-8(w)-329.8(Y)0(o)-6.4(r)0(k)]TJ
-6.5669 -1.6503 TD
(E-mail)Tj
/F1 1 Tf
2.7315 0 TD
[(:)-333.6(calif)-9.2(ano@c2b)-8.3(2.colum)-7.3(bia.edu)]TJ
/F4 1 Tf
6.4588 -1.7527 TD
[(Manol)-9.3(is)-335.5(Kellis)]TJ
-31.5712 -1.2007 TD
[(Associate)-342.5(Professor)-10.3(,)-336.1(MIT)-336.3(Computer)-344.8(Science)-339.6(and)-338(Articial)-345.1(Intelligence)-342.3(La)-6.4(boratory)-343.1(\(CSAIL\))]TJ
26.6033 -1.2007 TD
[(Cambr)-8(idge)-7.6(,)-330.4(Mass)-8.2(achuse)-9.3(tts)]TJ
.8251 -1.6503 TD
[(E-m)-8(ail)]TJ
/F1 1 Tf
2.7372 0 TD
[(:)-333.6(manoli@)-9.9(mit.edu)]TJ
/F4 1 Tf
-.6601 -1.747 TD
[(Gus)-7.4(tavo)-337.7(Stolovitz)-9.5(ky)]TJ
-19.0918 -1.2007 TD
[(Manag)-6.6(er,)-334.9(Funct)-8.2(ional)-333.7(Gen)-8(omics)-337.8(and)-338(Systems)-342.3(Biology)-342.5(Group,)-339.4(IBM)]TJ
12.4566 -1.2007 TD
[(Thoma)-7(s)-332(J)0(.)-338.7(Watson)-341.3(Research)-343.7(Cente)-9.2(r)]TJ
2.7884 -1.2007 TD
[(Yorktow)-9.3(n)-330.8(Height)-10.1(s,)-332.4(Ne)-8(w)-329.8(Y)0(o)-6.4(r)0(k)]TJ
.7284 -1.6503 TD
(E-mail)Tj
/F1 1 Tf
2.7315 0 TD
[(:)-339.3(gustavous)-8.1(.ibm.com)]TJ
/F2 1 Tf
8.9663 0 0 8.9663 107.6031 738.0848 Tm
[(JOURNAL)-334.2(OF)-337.5(COMPUTATIONAL)-337.8(BIOLOGY)]TJ
0 -1.2203 TD
[(Volume)-336.3(19,)-330.7(Number)-333.3(2,)-337.5(2012)]TJ
/F5 1 Tf
0 -1.2266 TD
(#)Tj
/F2 1 Tf
1.3341 0 TD
[(Mary)-331.2(Ann)-334.1(Liebert,)-339.1(Inc.)]TJ
-1.3341 -1.2203 TD
[(P.)-331(101)]TJ
T*
[(DOI:)-331.1(10.1089/cmb.2012.010p)]TJ
9.9626 0 0 9.9626 315.3259 34.9228 Tm
(101)Tj
ET
endstream
endobj
21 0 obj
<>
endobj
22 0 obj
<>
endobj
30 0 obj
<>stream
htXyTgoPHUR1*A1BD7DEefnvED(ahL1'{f2dm>rΫyy9wέ[!yxx<q˦yA K^yz~^~< S˞6GE,eNjrLR\wߗ=A ەRYD*='KLX ed=H9rTIT*lje9q tqf8,`L((;03G*'= MMHIM.c "yD>"J$=D/D=DDEW=EE Z$yHDT",c~ƭW=:Nۄ/I>dyMB6t;{d|&lp|/OII|j|/L:/riS%SoO?Jvm>q~Q+I?VxnXYjr}B74?'ַ`]YK
ӻWSu=ه%>M3,xl۸ʈK4<EFy4ÇsK!N|`BaI~,*q""\1k>sۍFו /PZ;0$1UL䋟iZRJLc^̅>n7pw-<Cu3߸s͠qLJf_v8m^'̀ע{9_x,L$ڴf6501iᮖ9S͓ZS[
&ބx&